2. Signaling Pathways
  3. Immunology/Inflammation
  4. NO Synthase

NO Synthase

Nitric oxide synthases; NOS

NO Synthase

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Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.

NO Synthase Isoform Specific Products:

NO Synthase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N8012
    Multinoside A
    		Inhibitor
    Multinoside A (compound 6) is an antioxidant with DPPH free radical scavenging activity (IC50=54.3 μg/mL). Multinoside A can also downregulate COX-2 expression (IC50=9.6 μg/mL) and inhibit NO production (IC50=43.9 μg/mL).
    Multinoside A
  • HY-149671
    Anti-inflammatory agent 63
    		Inhibitor
    Anti-inflammatory agent 63 is an anti-inflammatory agent that shows optimal inhibitory activity (EC50 = 5.33±0.57 μM) against the production of nitric oxide (NO) induced by lipopolysaccharide (LPS) in RAW264.7 cells.
    Anti-inflammatory agent 63
  • HY-107744R
    Nalmefene (Standard)
    		Inhibitor
    Nalmefene (Standard) is the analytical standard of Nalmefene. This product is intended for research and analytical applications. Nalmefene is a long acting opioid (MOR and DOR antagonist), and a partial KOR agonist. Nalmefene is used for opioid overdose and alcohol dependence.
    Nalmefene (Standard)
  • HY-N15334
    Tricrozarin A
    		Inhibitor
    Tricrozarin A is a Naphthazarin (HY-N7526) derivative, which is found in fresh bulbs of Tritonia crocosmaeflora. Tricrozarin A exhibits antimicrobial activity against gram-positive bacteria, fungi, and yeast.
    Tricrozarin A
  • HY-10230R
    Midostaurin (Standard)
    		Activator
    Midostaurin (Standard) is the analytical standard of Midostaurin. This product is intended for research and analytical applications. Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM. Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects.
    Midostaurin (Standard)
  • HY-N2237R
    Piceatannol 3'-O-glucoside (Standard)
    		Activator
    Piceatannol 3'-O-glucoside (Standard) is the analytical standard of Piceatannol 3'-O-glucoside. This product is intended for research and analytical applications. Piceatannol 3'-O-glucoside, an active component of Rhubarb, activates endothelial nitric oxide (NO) synthase through inhibition of arginase activity with IC50s of 11.22 μM and 11.06 μM against arginase I and arginase II, respectively.
    Piceatannol 3'-O-glucoside (Standard)
  • HY-N1330
    Rubranol
    		Inhibitor
    Rubranol is an inhibitor of NO Synthase. Rubranol inhibits LPS-induced NO production in activated macrophages with 74% inhibition.
    Rubranol
  • HY-N9086A
    (rac)-Poriol
    		Ligand
    (rac)-Poriol (5,7,4'-Trihydroxy-6-methylflavanone) exhibits antioxidant activity, and scavenges free radical DPPH with an IC50 of 0.18 µg/mL. (rac)-Poriol inhibits the LPS (HY-D1056)-induced NO generation in RAW264.7 (98.35% inhibition rate at 10 μM), and exhibits anti-inflammatory activity. (rac)-Poriol exhibits good binding affinity with iNOS, COX-1, COX-2, TNF-α, and IL-1β.
    (rac)-Poriol
  • HY-N0761AR
    trans-Isoferulic acid (Standard)
    		Inhibitor
    trans-Isoferulic acid (Standard) is the analytical standard of trans-Isoferulic acid. This product is intended for research and analytical applications. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity.trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1).
    trans-Isoferulic acid (Standard)
  • HY-N6968R
    α-Humulene (Standard)
    		Inhibitor
    α-Humulene (Standard) is the analytical standard of α-Humulene. This product is intended for research and analytical applications. α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC50=15±2 μg/mL). α-Humulene inhibits COX-2 and iNOS expression.
    α-Humulene (Standard)
  • HY-123581R
    Quinocetone (Standard)
    		Activator
    Quinocetone (Standard) is the analytical standard of Quinocetone (HY-123581). This product is used for research and analytical purposes. Quinocetone is an orally active animal feed additive used to increase the meat production of livestock and poultry. Quinocetone exhibits antibacterial activity against a variety of pathogenic microorganisms. Quinocetone exhibits tissue-specific (liver, lymphocyte) toxicity. Quinocetone induces autophagy in cells through the ATF6/DAPK1 pathway. Quinocetone activates the NF-κB and iNOS pathways, leading to cell apoptosis, hepatocyte vacuolar degeneration and fibrosis. Quinocetone can inhibit Nrf2/HO-1 and induce the generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage.
    Quinocetone (Standard)
  • HY-N13706
    3β,15α-Dihydroxy-7,11,23-trioxo-lanost-8-dien-26-oic acid
    		Inhibitor
    3β,15α-Dihydroxy-7,11,23-trioxo-lanost-8-dien-26-oic acid is a triterpene compound that can be found in Ganoderma lucidum, and it inhibits nitric oxide (NO) production in BV-2 microglial cells induced by lipopolysaccharide (LPS, HY-D1056), with an IC50 of 6.50 μM, making it a potential candidate for anti-inflammatory research.
    3β,15α-Dihydroxy-7,11,23-trioxo-lanost-8-dien-26-oic acid
  • HY-N15272
    Artocarpesin
    		Inhibitor
    Artocarpesin is a flavonoid compound. Artocarpesin has inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA). Artocarpesin inhibits the production of NO, PGE2 and ROS by inhibiting COX-2 and iNOS expression, and plays an anti-inflammatory role. In addition, Artocarpesin inhibits platelet aggregation by inhibiting cyclic nucleotides and MAPKs, which can be used in the study of cardiovascular diseases.
    Artocarpesin
  • HY-N16632
    1-O-Caffeoylglycerol
    		Inhibitor
    1-O-Caffeoylglycerol is a compound with anti-inflammatory activity isolated from Sorghum bicolor. 1-O-Caffeoylglycerol significantly inhibits LPS (HY-D1056) induced NO production (IC50 = 18.5 μM) and dose dependently inhibits iNOS protein expression. 1-O-Caffeoylglycerol can be used for research on inflammatory conditions.
    1-O-Caffeoylglycerol
  • HY-Y0078S1
    Cinnamyl Alcohol-d9
    		Inhibitor
    Cinnamyl Alcohol-d9 is deuterated labeled Cinnamyl Alcohole (HY-Y0045). Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities.
    Cinnamyl Alcohol-d<sub>9</sub>
  • HY-101410A
    SDMA (p-hydroxyazobenzene-p′-sulfonate)
    		Inhibitor
    SDMA p-hydroxyazobenzene-p′-sulfonate is the p-hydroxyazobenzene-p′-sulfonate salt form of SDMA (HY-101410). SDMA p-hydroxyazobenzene-p′-sulfonate is an endogenous inhibitor of nitric oxide synthase (NO synthase) activity. SDMA p-hydroxyazobenzene-p′-sulfonate is an activator for NF-κB, and promotes the expression of IL-6 and TNF-α. SDMA p-hydroxyazobenzene-p′-sulfonate is stable in serum and plasma, and can be used as a kidney biomarker of hepatic and renal dysfunction.
    SDMA (p-hydroxyazobenzene-p′-sulfonate)
  • HY-133198
    Valeriandoid B
    		Inhibitor
    Valeriandoid B is a Iridoids product that can be isolated from the herbs of Valeriana jatamansi.
    Valeriandoid B
  • HY-N0577R
    Apiin (Standard)
    		Inhibitor
    Apiin (Standard) is the analytical standard of Apiin. This product is intended for research and analytical applications. Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells.
    Apiin (Standard)
  • HY-N12317
    Multiflorin B
    Multiflorin B (compound 5) is a kind of kaempferol glycoside. Multiflorin B can be isolated from the root of the fern Neocheiropteris palmatopedata. Multiflorin B inhibits nitric oxide production at a concentration of 20 μg/ml with an inhibition of 52%.
    Multiflorin B
  • HY-155224
    Sulpho NONOate
    		Control
    Sulpho NONOate (Sulfi/NO) does not produce NO at physiological pH. Sulpho NONOate can be used in the experiments about other NO-donor regents as a negative control.
    Sulpho NONOate
Cat. No. Product Name / Synonyms Application Reactivity
NO Synthase Isoform Comparison

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